DSCAM associates with Rac1-GTP:pPAK1 Authored: Garapati, P V, 2010-01-05 DSCAM directly binds to serine/threonine-protein kinase PAK1 and this interaction is enhanced by the presence of Rac1 protein. Rac1 interacts with the CRIB motif in the N-terminal domain of PAK1 and DSCAM interacts with the kinase domain of PAK1. Rac1-bound PAK1, which is already active, has higher affinity for DSCAM, which may further regulate PAK1 activation. Edited: Garapati, P V, 2010-01-05 Pubmed15169762 Reactome Database ID Release 43376123 Reactome, http://www.reactome.org ReactomeREACT_24940 Reviewed: Clemens, JC, 2010-08-10 DSCAM:pPAK(S144):Rac1-GTP pPAK(S144):Rac1-GTP