Nephrin trans-homophilic interaction Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 Edited: Garapati, P V, 2010-03-01 Foot processes are long slender, actin rich protrusions of the cytoplasm that are anchored to the glomerular basement membrane. Adjacent foot processes are laterally interconnected by a highly specialized cell cell junction, the so called slit diaphragm (SD). Nephrin is the critical structural component within the slit diaphragm. Nephrin molecules of adjacent foot processes from neighboring podocytes interact with each other in the middle of the slit diaphragm forming a filter with a zipper like structure and with pores just the size of albumin on both sides of the midline density. Pubmed10393930 Pubmed10541305 Pubmed12660326 Pubmed14633607 Pubmed15545998 Pubmed17893108 Reactome Database ID Release 43373732 Reactome, http://www.reactome.org ReactomeREACT_23987 Reviewed: Huber, TB, Grahammer, Florian, 2010--0-5- has a Stoichiometric coefficient of 2 Nephrin dimer