ABCAs mediate lipid efflux ABCA3 plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol (Klugbauer and Hofmann 1996, Yamano et al. 2001). Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921] (Shulenin et al. 2004).<br>The exact roles of ABCA2 (Vulevic et al. 2001, Kaminski et al. 2001), ABCA6 (Kaminski & Wenzel et al. 2001), ABCA9 (Piehler et al. 2002), ABCA10 (Wenzel et al. 2003) and ABCA12 (Annilo et al. 2002), candidates for ABC lipid transporter-related activities, need to be elucidated. Even thought cholesterol-responsiveness has been noted in experimental systems, contribution of these proteins in regulation or in active transport is not yet clear. Authored: Jassal, B, 2011-07-04 Edited: Jassal, B, 2011-07-04 Pubmed11178988 Pubmed11309290 Pubmed11435397 Pubmed11478798 Pubmed11718719 Pubmed12150964 Pubmed12697999 Pubmed12821155 Pubmed12915478 Pubmed15044640 Reactome Database ID Release 431369028 Reactome, http://www.reactome.org ReactomeREACT_111067 Reviewed: D'Eustachio, P, 2011-08-23 Reviewed: Matthews, L, 2008-12-02 15:41:53