Interaction of IQGAP1 with nephrin Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 Edited: Garapati, P V, 2010-03-01 IQGAP1, an effector protein of the small GTPases Rac1 and Cdc42 and a putative regulator of cell-cell adherens junctions, is expressed in podocytes at significant levels, and located in the immediate vicinity of the slit diaphragm. IQGAP1 is identified as one of the interacting partners of nephrin. This interaction takes place strictly and specifically between the C-terminal half of the nephrin intracellular domain and IQGAP1. IQGAP1 knock-out mouse does not have any obvious nephrotic phenotype, hence IQGAP1 function can either be substituted by other proteins or its role in vivo is much less important than that attributed to it from cell culture experiments. Pubmed10611248 Pubmed15331416 Pubmed15634346 Pubmed15994232 Reactome Database ID Release 43451377 Reactome, http://www.reactome.org ReactomeREACT_24018 Reviewed: Huber, TB, Grahammer, Florian, 2010--0-5- Nephrin dimer:NEPH1 Nephrin dimer:IQGAP1