Nephrin binds CASK Authored: de Bono, B, Garapati, P V, 2008-02-26 12:30:30 CASK is a scaffolding protein that participates in maintenance of polarized epithelial cell architecture by linking membrane proteins and signaling molecules to the actin cytoskeleton. CASK is identified as one of the binding partners of nephrin and this interaction likely plays an important role in establishing the structural integrity and functional properties of the glomerular slit diaphragm. Edited: Garapati, P V, 2010-03-01 Pubmed15331416 Reactome Database ID Release 43373722 Reactome, http://www.reactome.org ReactomeREACT_23922 Reviewed: Huber, TB, Grahammer, Florian, 2010--0-5- Nephrin dimer:CASK Nephrin dimer:NEPH1