Phosphorylation of the Emi1 DSGxxS degron by Plk1 Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00 EC Number: 2.7.11 Edited: Matthews, L, 2006-02-17 05:22:55 Pubmed15469984 Reactome Database ID Release 43174174 Reactome, http://www.reactome.org ReactomeREACT_6861 Reviewed: Peters, JM, 2006-03-27 22:55:09 The phosphorylation of Emi1 by Plk1 is believed to be involved in the degradation of Emi1 during mitosis. Plk1 phosphorylates serine residues in the DSGxxS degron sequence of Emi1 recruiting the SCF(betaTrCP) ubiquitin ligase. has a Stoichiometric coefficient of 2 Emi1:Cdc20/Cdh1 complex phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes