PDS5 Cohesin binds PDS5 and WAPAL Authored: Orlic-Milacic, M, 2012-10-02 Edited: Gillespie, ME, 2012-10-05 Edited: Matthews, L, 2012-10-05 Pubmed17112726 Pubmed17113138 Pubmed19696148 Reactome Database ID Release 432468040 Reactome, http://www.reactome.org ReactomeREACT_150350 Reviewed: Zhang, Nenggang, 2012-10-22 WAPAL (WAPL) and PDS5 proteins (PDS5A and/or PDS5B) are associated with cohesin throughout most of the cell cycle (Kueng et al. 2006, Gandhi et al. 2006). FGF motifs present in the N-terminal region of WAPAL participate in WAPAL binding to PDS5 and cohesin subunits RAD21, STAG1 (SA1) and STAG2 (SA2) (Shintomi and Hirano 2009). Cohesin Complex Cohesin:PDS5:WAPAL