Deacetylation of cleaved cohesin Authored: Orlic-Milacic, M, 2012-10-02 Edited: Gillespie, ME, 2012-10-05 Edited: Matthews, L, 2012-10-05 Histone deacetylase HDAC8 deacetylates SMC3 cohesin subunit. SMC3 deacetylation promotes dissociation of cleaved RAD21 fragments from other cohesin proteins and their replacement with intact RAD21, thereby allowing restoration of the cohesin complex (Deardorff et al. 2012). HDAC8 mutations, as well as mutations in NIPBL, SMC1A and SMC3, can cause Cornelia de Lang syndrome (Deardorff et al. 2012). Pubmed22885700 Reactome Database ID Release 432545203 Reactome, http://www.reactome.org ReactomeREACT_150294 Reviewed: Zhang, Nenggang, 2012-10-22 has a Stoichiometric coefficient of 2 PDS5 Cohesin Complex Cleaved Cohesin:PDS5:WAPAL