Separation of sister chromatids Authored: Orlic-Milacic, M, 2012-10-02 Edited: Gillespie, ME, 2012-10-05 Edited: Matthews, L, 2012-10-05 Pubmed11081627 Pubmed11509732 Pubmed12194817 Reactome Database ID Release 432467811 Reactome, http://www.reactome.org ReactomeREACT_150148 Reviewed: Zhang, Nenggang, 2012-10-22 The cleavage of RAD21 subunit of centromeric cohesin by ESPL1 (separin i.e. separase) promotes dissociation of cohesin complexes from centromeric chromatin at the onset of anaphase, allowing for sister chromatid separation and segregation of replicated chromosomes to daughter cells (Waizenegger et al. 2000, Hauf et al. 2001, Waizenegger et al. 2002). has a Stoichiometric coefficient of 2 Cleaved Cohesin:PDS5:WAPAL Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules Sister Centromere:Kinetochore:Microtubules