Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions Authored: Matthews, L, 2009-05-15 19:26:33 Edited: Matthews, L, 2009-05-18 16:34:30 Edited: Matthews, L, 2009-08-19 PAR-3 exists in a ternary complex with aPKC and PAR-6 to form the PAR-aPKC complex (Macara, 2004; Suzuki and Ohno, 2006). This complex is critically involved in the development of Tight Junctions (TJs) from primordial spot-like Adherens Junctions (AJs) (Suzuki et al., 2002). PAR-3 directly interacts with Junctional Adhesion Molecules (JAM)-A, -B, and -C (Ebnet et al., 2001; Ebnet et al., 2004).The interaction with JAM-A might anchor the PAR-aPKC complex to TJs but might also be necessary to recruit the PAR-aPKC complex to primordial spot-like AJs where it becomes activated in response to cell-cell adhesion (reviewed in (Ebnet et al., 2008). The PAR-aPKC complex might also be physically linked to the second polarity protein complex at TJs, the CRB3-Pals1-PATJ complex through a direct interaction between PAR-6 and Pals1 (Hurd et al., 2003). Pubmed11447115 Pubmed12186943 Pubmed12545177 Pubmed12953056 Pubmed14657270 Pubmed14991002 Pubmed16525119 Pubmed18508678 Reactome Database ID Release 43419981 Reactome, http://www.reactome.org ReactomeREACT_19353 Reviewed: Ebnet, K, 2009-08-26 JAM-A:PAR-aPKC complex Par3:Par6:aPKC complex