Crumbs forms a ternary complex with Pals1 and PATJ at tight junctions Authored: Matthews, L, 2009-05-15 19:26:33 Edited: Matthews, L, 2009-05-18 16:34:30 Pubmed11964389 Pubmed12771187 Pubmed15738264 Pubmed16129888 Pubmed16771626 Reactome Database ID Release 43420661 Reactome, http://www.reactome.org ReactomeREACT_19144 Reviewed: Ebnet, K, 2009-08-26 The CRB3–Pals1–PATJ complex is the second major cell polarity protein complex at Tight Junctions (TJs) (Shin et al., 2006). The integral membrane protein CRB3 localizes to the apical domain of epithelial cells and is concentrated at TJs. CRB3 directly associates with Pals1 which interacts with PATJ, a proteins consisting of 10 PDZ domains. The interaction with CRB3 might recruit the Pals1-PATJ complex to TJs (Lemmers et al., 2002; Roh et al., 2003). Although its precise functions of the individual components have not been established, the complex is required for TJ formation, in part through the stabilization of apical and lateral components of tight junctions (Michel et al., 2005; Shin et al., 2005). CRB3:PALS1:PATJ complex