Beta-catenin/gamma catenin Classic Cadherin Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin Authored: Matthews, L, 2009-05-15 19:26:33 Edited: Matthews, L, 2009-08-26 Pubmed16025097 Pubmed16325583 Pubmed17005550 Pubmed17158740 Pubmed18093941 Pubmed7806582 Reactome Database ID Release 43419002 Reactome, http://www.reactome.org ReactomeREACT_19131 Reviewed: Ebnet, K, 2009-08-26 The cytoplasmic tails of classical cadherins form a multiprotein complex with alpha-catenin, beta/gamma-catenins and p120 catenin (p120ctn) (Gumbiner, 2005). Beta-catenin and p120ctn directly interact with the cadherin molecule through highly conserved regions in the membrane-distal and membrane-proximal domains, respectively, of the cadherin. The interactions with beta-catenin and p120ctn regulate cadherin localization at cell-cell contacts as well as its adhesive activity (Halbleib and Nelson, 2006). The association of beta-catenin and alpha-catenin probably serves to link the cadherin-catenin complex to the F-actin cytoskeleton through the protein ELPIN (Abe and Takeichi, 2008). Independently of its association with the cadherin-catenin complex, alpha-catenin also regulates the bundling and growth of actin filaments at sites of cell-cell contact formation (Drees et al., 2005; Weis and Nelson, 2006). Cadherin:Catenin complex