Interaction of Nectins with Afadin Authored: Matthews, L, 2009-05-15 19:26:33 Edited: Matthews, L, 2009-08-26 Nectins are immunoglobulin-like cell adhesion molecules comprising a family of four members, nectin 1 - 4 (Takai and Nakanishi, 2003). In contrast to classical cadherins which interact only homophilically, nectins undergo trans-homophilic and trans-heterophilic interactions with nectins and nectin-like molecules (Takai et al., 2008b). Nectins cooperate with cadherins in regulating the formation of adherens junctions (AJs) and the strength of cell-cell adhesion. Nectins are linked to the underlying actin cytoskeleton through their interaction with the actin-binding protein Afadin (Takai et al., 2008a). Nectin-based cell–cell adhesions contribute to formation of many types of cell-cell junctions including AJs, tight junctions, and synaptic junctions. Pubmed10225955 Pubmed12456712 Pubmed18648374 Reactome Database ID Release 43419003 Reactome, http://www.reactome.org ReactomeREACT_19214 Reviewed: Ebnet, K, 2009-08-26 Nectin Nectin:afadin complex