RFC binding displaces Pol Alpha on the C-strand of the telomere Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000722 Once the RNA-DNA primer is synthesized, replication factor C (RFC) initiates a reaction called "polymerase switching"; pol delta, the processive enzyme replaces pol alpha, the priming enzyme. RFC binds to the 3'-end of the RNA-DNA primer on the Primosome, to displace the pol alpha primase complex. The binding of RFC triggers the binding of the primer recognition complex. Pubmed10656791 Pubmed10656792 Pubmed1671046 Reactome Database ID Release 43174452 Reactome, http://www.reactome.org ReactomeREACT_8008 Reviewed: Price, C, 2006-07-13 18:33:38 RFC Heteropentamer primosome RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end RNA primer-DNA primer:G-strand extended telomere