Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000722 Pubmed10748138 Pubmed11473323 Reactome Database ID Release 43174441 Reactome, http://www.reactome.org ReactomeREACT_7955 Reviewed: Price, C, 2006-07-13 18:33:38 The Dna2 endonuclease removes the initiator RNA along with several downstream deoxyribonucleotides. The cleavage of the single-stranded RNA substrate results in the disassembly of RPA and Dna2. The current data for the role of the Dna2 endonuclease has been derived from studies with yeast and Xenopus Dna2. RPA heterotrimer Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:dna2 Processive complex loaded on telomere:Okazaki fragments:Remaining Flap