Formation of Processive Complex on the C-strand of the telomere Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000722 Pubmed1682322 Pubmed1974050 Pubmed7713898 Pubmed8104944 Reactome Database ID Release 43174448 Reactome, http://www.reactome.org ReactomeREACT_7979 Reviewed: Price, C, 2006-07-13 18:33:38 The loading of proliferating cell nuclear antigen (PCNA) leads to recruitment of pol delta. Human PCNA is a homotrimer of 36 kDa subunits that form a toroidal structure. The loading of PCNA by RFC is a key event in the transition from the priming mode to the extension mode of DNA synthesis. The processive complex is composed of the pol delta holoenzyme and PCNA. DNA Polymerase delta tetramer Processive complex loaded on telomere RNA primer-DNA primer:G-strand extended telomere:PCNA