Joining of adjacent Okazaki fragments of the C-strand Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000722 Pubmed10959839 Pubmed8392066 Pubmed9081985 Pubmed9759502 Reactome Database ID Release 43174456 Reactome, http://www.reactome.org ReactomeREACT_7994 Removal of the flap by FEN-1 leads to the generation of a nick between the 3'-end of the upstream Okazaki fragment and the 5'-end of the downstream Okazaki fragment. DNA ligase I then seals the nicks between adjacent processed Okazaki fragments to generate intact double-stranded DNA at the telomere. Reviewed: Price, C, 2006-07-13 18:33:38 Processive complex loaded on telomere:ligated C-strand Okazaki fragments Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments