Formation of the telomere bouquet As sections of the axial elements form, the telomeres migrate to one site on the inner nuclear membrane to form the telomere bouquet (Scherthan et al. 1996). A current model shows the synaptonemal complex interacting with SUN1 and SUN2, which span the inner membrane and bind Nesprin-1 and Nesprin-2, which span the outer membrane and bind cytoplasmic actin. Lamin-B1 and Lamin-C2 are located adjacent to the attachment plate on the inner membrane. Authored: May, B, 2010-07-19 Edited: May, B, 2010-07-19 Pubmed8794855 Reactome Database ID Release 43912408 Reactome, http://www.reactome.org ReactomeREACT_75817 Reviewed: Bolcun-Filas, E, 2011-02-25 Reviewed: Cohen, PE, 2011-02-04 Reviewed: Holloway, JK, 2011-02-04 Reviewed: Lyndaker, A, 2011-02-25 Reviewed: Schimenti, JC, 2011-02-04 Reviewed: Strong, E, 2011-02-25 Telomere clustering at the nuclear membrane Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure Axial/Lateral Element of Synaptonemal Complex Telomere Bouquet