Recruitment of BRCA1 to Unsynapsed Regions Authored: May, B, 2010-07-19 Edited: May, B, 2010-07-19 Pubmed19146767 Pubmed9008167 Reactome Database ID Release 43912467 Reactome, http://www.reactome.org ReactomeREACT_75884 Reviewed: Bolcun-Filas, E, 2011-02-25 Reviewed: Cohen, PE, 2011-02-04 Reviewed: Holloway, JK, 2011-02-04 Reviewed: Lyndaker, A, 2011-02-25 Reviewed: Schimenti, JC, 2011-02-04 Reviewed: Strong, E, 2011-02-25 Unsynapsed regions of chromosomes are silenced during pachytene phase by a process called Meiotic Silencing of Unsynapsed Chromatin (MSUC) and, in the case of the X and Y chromosomes, Meiotic Sex Chromosome Inactivation (MSCI). Unsynapsed meiotic chromatin recruits BRCA1 (Scully et al. 1997, Garcia-Cruz et al. 2009). In mouse, the recruitment requires SYCP3 of axial elements of the synaptonemal complex, which may remain exposed in unsynapsed regions. Synaptonemal:BRCA1 Complex Unsynapsed Chromatin