APC/C:Cdh1-mediated degradation of Skp2 Authored: Pagano, M, 2006-09-19 08:23:10 Edited: Matthews, L, 2006-10-01 21:26:42 Pubmed15014502 Pubmed15014503 Reactome Database ID Release 43188191 Reactome, http://www.reactome.org ReactomeREACT_9035 Reviewed: Peters, JM, 2006-03-27 22:55:09 Skp2 is degraded by the anaphase promoting complex/Cyclosome and its activator Cdh1 [APC/C(Cdh1)] (Bashir et al, 2004; Wei et al, 2004). The tight regulation of APC/C(Cdh1) activity ensures the timely elimination Skp2 and, thus, plays a critical role in controlling the G1/S transition. has a Stoichiometric coefficient of 4 ubiquitin phospho-APC/C:Cdh1 complex multiubiquitinated Skp2:phospho-APC/C:Cdh1 complex