HJURP:CENPA Complex Localizes to the Centromere. Authored: May, B, 2010-04-15 Edited: May, B, 2010-04-15 Pubmed17199038 Pubmed19410544 Pubmed19410545 Pubmed20080577 Reactome Database ID Release 43606326 Reactome, http://www.reactome.org ReactomeREACT_22146 Reviewed: Almouzni-Pettinotti, G, Dunleavy, EM, 2010-05-30 Reviewed: Foltz, DR, 2010-06-14 The HJURP complex binds free, newly synthesized CENPA-H4 tetramers. A direct interaction occurs between HJURP and CENPA. The CATD domain of CENPA is sufficient for the interaction. The complex then localizes to the centromere in early G1 phase. HJURP is required for deposition of new CENPA-containing nucleosomes. Centromeric Chromatin:CENPH-I:Mis18:HJURP:CENPA Complex HJURP:CENPA Complex Centromeric Chromatin:CENPH-I: Mis18 Complex