Disassociation of Telomerase RNP and the Chromosome End Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0007004 In vitro, telomerase can disassociate from the primer following addition of each nucleotide or during the translocation step. The regulation of telomerase disassociation from the telomere in vivo is not well-characterized. One factor that may be involved is a helicase termed hPIF1, which can unanneal the telomerase RNA/telomeric DNA hybrid (Boule et al., 2005; Zhang et al., 2006).<br> Pubmed11850778 Pubmed14690602 Pubmed15189140 Pubmed15316005 Pubmed16121131 Pubmed16522649 Reactome Database ID Release 43163120 Reactome, http://www.reactome.org ReactomeREACT_7996 Reviewed: Price, C, 2006-07-13 18:33:38 Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats Telomerase RNP