Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00 Edited: Matthews, L, 2004-11-18 13:25:08 Edited: Matthews, L, 2006-02-17 00:25:47 GENE ONTOLOGYGO:0051437 One model ( the direct inhibition model) describing the inhibition of the APC/C during the mitotic spindle checkpoint suggests that the association of the hBUBR1:hBUB3:MAD2*:CDC20 mitotic checkpoint complex (MCC) with APC/C results in the inactivation of APC/C. The affinity between MCC and APC/C is not high, thus inhibition is readily reversible when the mitotic spindle checkpoint has been satisfied. Pubmed11535616 Reactome Database ID Release 43174238 Reactome, http://www.reactome.org ReactomeREACT_6733 Reviewed: Peters, JM, 2006-03-27 22:55:09 hBUBR1:hBUB3:MAD2* complex CDC20:p-APC/C MCC:APC/C complex