Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) 'SREBP1A/2:NF-Y:HMGCR gene [nucleoplasm]' positively regulates 'Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)' ACTIVATION Pubmed11485325 Pubmed11994399 Pubmed18654640 Pubmed8647822 Pubmed8833906 Pubmed9062341 Pubmed9616204 Pubmed9748295 Reactome Database ID Release 431655873 Reactome, http://www.reactome.org ReactomeREACT_118005 SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Hydroxymethylglutaryl CoA Reductase gene (HMGCR) and enhance transcription (Shimano et al. 1996,Vallett et al. 1996, Shiman et al. 1997, Horton et al. 1998, Pai et al. 1998, Sakakura et al. 2001, Reed et al. 2008, reviewed in Horton et al. 2002). SREBP1A/2:NF-Y:HMGCR gene