'Methylcytosine: MBD2 Complex [nucleoplasm]' negatively regulates 'UBF-1 Binds rDNA Promoter' INHIBITION Methylcytosine in the promoter of a rRNA gene binds MBD2 (and possibly other Methyl Domain Binding Proteins) and prevents the transcription factor UBF-1 from binding. In mouse, methylation of the cytosine 133 nucleotides upstream of the start of transcription is sufficient. In the human rRNA promoter methylation of cytosines 9, 102, and 347 nucleotides upstream inhibit transcription. Pubmed11583633 Pubmed14610093 Reactome Database ID Release 43427398 Reactome, http://www.reactome.org ReactomeREACT_20487 Methylcytosine: MBD2 Complex UBF-1 Binds rDNA Promoter