CAK-mediated phosphorylation of Cyclin E:Cdk2 Authored: Pagano, M, 2006-09-19 08:23:10 Edited: Matthews, L, 2006-09-28 04:25:14 Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK kinase activity. The association of p21/p27 with the Cyclin A/E:Cdk2 complex prevents CAK mediated phosphorylation of Cdk2 (Aprelikova et al., 1995). Pubmed7629134 Reactome Database ID Release 43188350 Reactome, http://www.reactome.org ReactomeREACT_9067 Reviewed: Coqueret, O, 2006-10-06 08:59:06 Cyclin E:Phosho-Cdk2 (Thr 160) Cyclin E:Cdk2 complexes