p130 (RBL2) binds Cyclin E/A:CDK2 Authored: Orlic-Milacic, Marija, 2011-06-14 Pubmed9199292 Reactome Database ID Release 431363306 Reactome, http://www.reactome.org ReactomeREACT_111079 Reviewed: MacPherson, D, 2011-08-25 p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction. Cyclin E/A:Cdk2 RBL2:Cyclin E/A:CDK2