p107 (RBL1) binds CyclinE/A:CDK2 Authored: Orlic-Milacic, Marija, 2011-06-14 Pubmed9199292 Reactome Database ID Release 431363314 Reactome, http://www.reactome.org ReactomeREACT_111202 Reviewed: MacPherson, D, 2011-08-25 p107 (RBL1) is able to bind complexes of CDK2 with either cyclin A or cyclin E, through cyclin-binding LFG motif in the pocket domain, which is conserved in p130 (RBL2) and p21/WAF1/Cip1 family of cyclin-dependent kinase inhibitors. In addition to the LFG motif, the amino terminal sequence conserved in the p107 (RBL1) and p130 (RBL2) is needed for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction. RBL1:Cyclin E/A:CDK2 Cyclin E/A:Cdk2