Binding of the MCC complex to the APC/C complex Authored: Yen, T, 2004-05-05 00:00:00 Edited: Matthews, L, 2006-03-07 23:46:51 In the direct inhibition model, association of the MCC with APCC results in the inactivation of APC/C. However, the affinity between MCC and APC/C is not high, so that the inhibition is readily reversible. The role of unattached kinetochores is to sensitize the APC/C to prolonged inhibition by the MCC. Pubmed11535616 Reactome Database ID Release 43141423 Reactome, http://www.reactome.org ReactomeREACT_1951 Reviewed: Peters, JM, 2006-03-27 22:55:09 MCC:APC/C complex phosphorylated anaphase promoting complex (APC/C) hBUBR1:hBUB3:MAD2*:CDC20 complex