Inactivation of APC/C via CDC20 sequestration Authored: Yen, T, 2004-05-05 00:00:00 Edited: Matthews, L, 2006-02-17 05:19:32 In the sequestration model, the Mad2 molecules that dissociate from unattached kinetochores are perceived to bind to Cdc20, a protein that recruits specific substrates to the APC/C. Consequently, Mad2 indirectly inhibits the APC/C by sequestering its activator, Cdc20. This requires interaction between Mad1 and Mad2. Cdc20 and Mad1 bind to the same site on Mad2. Reactome Database ID Release 43141429 Reactome, http://www.reactome.org ReactomeREACT_433 Reviewed: Peters, JM, 2006-03-27 22:55:09 MAD2*CDC20 complex