Release of activated MAD2 from kinetochores Authored: Yen, T, 2004-05-05 00:00:00 Pubmed12006501 Reactome Database ID Release 43141439 Reactome, http://www.reactome.org ReactomeREACT_88 The mechanism by which the conformationally altered inhibitory form of Mad2 is released from its association with Mad1 at the kinetochore is not known. Mad1 and Cdc20 have a common 10 residue Mad2 binding motif. Therefore, one possibility is that Mad2 is transferred competitively from Mad1 to Cdc20 (Luo et al., 2002; Sironi et al., 2002). Kinetochore:Mad1:MAD2* Complex Mad1:kinetochore complex