Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 Authored: Pagano, M, 2006-09-19 08:23:10 EC Number: 2.7.11.22 Edited: Matthews, L, 2006-09-19 08:32:00 Pubmed10323868 Pubmed10375532 Pubmed10559916 Pubmed15130491 Reactome Database ID Release 43187520 Reactome, http://www.reactome.org ReactomeREACT_8998 Reviewed: Coqueret, O, 2006-10-06 08:59:06 The interaction between the Skp2 subunit of the SCF(Skp2) complex and p27 is dependent upon Cdk2:Cyclin A/E mediated phosphorylation of p27 at Thr 187 (Carrano et al, 1999; Tsvetkov et al, 1999). There is evidence that Cyclin A/B:Cdk1 can also bind and phosphorylate p27 on Thr 187 (Nakayama et al., 2004). This phosphorylation is also essential for the subsequent ubiquitination of p27. Cyclin E/A:Cdk2:phospho-p27/p21 Cyclin E/A:Cdk2:p27/p21 complex