Recruitment of Plk1 to centrosomes Authored: Matthews, L, 2008-11-11 14:53:40 Edited: Matthews, L, 2008-11-09 05:12:41 Plk1 is associated with the centrosomes early in mitosis (Golsteyn et al. 1995). Plk1 activity is necessary for the maturation of centrosomes at the G2/M transition and the establishment of a bipolar spindle (Lane and Nigg 1996). Specific inhibitors against Plk1 or silencing of Plk1 produce a monopolar mitotic apparatus (Sumara et al, 2004, van Vugt et al, 2004, McInnes et al, 2006, Peters et al, 2006, Lénárt et al, 2007). Pubmed15210710 Pubmed15458642 Pubmed17028580 Pubmed17028581 Pubmed17291761 Pubmed7790358 Pubmed8991084 Reactome Database ID Release 43380311 Reactome, http://www.reactome.org ReactomeREACT_15470 Reviewed: Merdes, A, 2008-11-17 13:55:29 Centrosome associated Plk1 centrosome