Cyclin B/Cdk1 mediate phosphorylation of NuMA After the initiation of DNA condensation during mitosis, NuMA is phosphorylated by Cdc2 kinase and transported rapidly to the centrosomal region (Hsu and Yeh, 1996). Another phosphorylation event occurs when NuMA associates with the mitotic spindle (Gaglio et al., 1995; Hsu and Yeh, 1996). While p34cdc2/cyclin B-dependent phosphorylation appears to plays an essential role in the targeting of NuMA to the spindle apparatus (Compton and Luo, 1995)(Hsu and Yeh, 1996), there may be additional protein kinases that promote the release of NuMA from the nuclear compartment at nuclear envelope breakdown (Saredi et al., 1997). Authored: Matthews, L, 2008-11-11 14:53:40 EC Number: 2.7.11.22 Edited: Matthews, L, 2008-11-09 05:12:41 Pubmed7593190 Pubmed7769006 Pubmed8838651 Pubmed9202389 Reactome Database ID Release 43380278 Reactome, http://www.reactome.org ReactomeREACT_15543 Reviewed: Merdes, A, 2008-11-17 13:55:29