Association of NuMA with microtubules Authored: Matthews, L, 2008-11-11 14:53:40 Edited: Matthews, L, 2008-11-09 05:12:41 Edited: Matthews, L, 2008-11-24 13:58:10 NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al., 1996; Gueth-Hallonet et al., 1998; Harborth et al., 1999) apparently as a result of dimerization of the NuMA rod domains followed by association of multiple NuMA dimers through their tail domains. Pubmed10075938 Pubmed11956313 Pubmed8907707 Pubmed9743603 Reactome Database ID Release 43380316 Reactome, http://www.reactome.org ReactomeREACT_15294 Reviewed: Merdes, A, 2008-11-17 13:55:29 NuMA homodimer centrosome-nucleated microtubules NuMA-bound microtubules