Kinetochore assembly Authored: Orlic-Milacic, M, 2012-10-02 Edited: Gillespie, ME, 2012-10-05 Edited: Matthews, L, 2012-10-05 Pubmed18097444 Reactome Database ID Release 432484822 Reactome, http://www.reactome.org ReactomeREACT_150388 Reviewed: Zhang, Nenggang, 2012-10-22 The kinetochore assembly on centromeres of replicated chromosomes is completed by mitotic prometaphase. Some kinetochore components are associated with centromeres throughout the cell cycle while others associate with centromeres during mitosis. The sequential kinetochore assembly and kinetochore dynamics is not shown here. For a review of this process, please refer to Cheeseman and Desai 2008. has a Stoichiometric coefficient of 2 Sister Centromeres:Ac-Cohesin:PDS5:CDCA5:WAPAL Microtubule-bound kinetochore Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules