Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation Authored: Gopinathrao, G, 2004-06-16 18:53:38 Reactome Database ID Release 43113638 Reactome, http://www.reactome.org ReactomeREACT_555 This event is inferred from the fission yeast. Cyclin B activity is thought to inhibit pre-RC formation by first associating with ORC during DNA replication. ORC:origin ORC:origin:cyclin B:cdk1 complex Cyclin B:Cdk1 complex