p21/p27 Inactivation of Cyclin A:Cdk2 complexes by p27/p21 Authored: Pagano, M, 2006-09-19 08:23:10 During G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 2006). Edited: Matthews, L, 2006-09-28 04:25:14 Pubmed10323868 Pubmed7624798 Reactome Database ID Release 43187934 Reactome, http://www.reactome.org ReactomeREACT_9005 Reviewed: Coqueret, O, 2006-10-06 08:59:06 Cyclin A:Cdk2:p21/p27 complex Cyclin A:Cdk2 complex