Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes Activation of the mitotic cyclin:Cdc2 complexes at mitosis requires the removal of the inhibitory phosphate groups on Cdc2. This dephosphorylation is achieved by the activity of the Cdc25 family of phosphatases. The Cdc25 members, Cdc25A, Cdc25B, and Cdc25C are kept inactive during interphase and are activated at the G2/M transition (see Wolfe and Gould 2004) EC Number: 3.1.3.16 Pubmed15107615 Reactome Database ID Release 43170158 Reactome, http://www.reactome.org ReactomeREACT_6294 has a Stoichiometric coefficient of 2 Cyclin A:phospho-Cdc2(Thr 161, Thr 14, Tyr 15) Cyclin A:phospho-Cdc2(Thr 161)