PathwayStep1741 PathwayStep1740 PathwayStep1737 PathwayStep1736 PathwayStep1739 PathwayStep1738 PS is hydrolyzed to 1-acyl LPS by PLA2[15] 2-acyl LPS is acylated to PS by LPSAT PS is hydrolyzed to 2-acyl LPS by PLA2[10] 1-acyl LPS is acylated to PS by LPSAT PS is hydrolyzed to 1-acyl LPS by PLA2G2A PS is hydrolyzed to 1-acyl LPS by PLA2[9] Acyl chain remodelling of PS Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0036150 In the acyl chain remodelling pathway (Lands cycle), phosphatidylserine (PS) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008; Hishikawa et al. 2008). Pubmed12359733 Pubmed18287005 Pubmed18458083 Pubmed20705608 Reactome Database ID Release 431482801 Reactome, http://www.reactome.org ReactomeREACT_121384