PathwayStep1687 PathwayStep1686 PathwayStep1685 PathwayStep1684 PathwayStep1689 PathwayStep1688 PathwayStep1682 PathwayStep1683 PS is decarboxylated to PE by PISD PE transports from the mitochondrial membrane to the ER PETA and CTP are condensed to CDP-ETA by PCY2 PETA is dephosphorylated to ETA by PHOSPHO1 ETA is phosphorylated to PETA by CHK/ETNK PS transports from the ER membrane to the IM membrane CDP-ETA and DAG are converted to PE by CEPT1/EPT1 PA is dephosphorylated to DAG by LPIN Synthesis of PE <i>De novo</i> (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CTP) to form CDP-ethanolamine (CDP-ETA). Diacylglycerol (DAG) and CDP-ETA together then form PE. Alternatively, PE is formed when phosphatidylserine (PS) is decarboxylated by phosphatidylserine decarboxylase proenzyme (PISD) (Henneberry et al. 2002, Vance 1991, Vance 1990). Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006646 Pubmed12221122 Pubmed1898727 Pubmed2332429 Reactome Database ID Release 431483213 Reactome, http://www.reactome.org ReactomeREACT_120919 Reviewed: Wakelam, Michael, 2012-05-14