PathwayStep1703 PathwayStep1704 PathwayStep1705 PathwayStep1706 PathwayStep1707 PathwayStep1708 PathwayStep1709 PathwayStep1711 PathwayStep1710 PathwayStep1685 PE is methylated to PC by PEMT Acetylcholine clearance from synaptic cleft CTL1-5 can mediate the uptake of choline Cho is phosphorylated to PCho by CHK dimer PCho is dephosphorylated to Cho by PHOSPHO1 Synthesis of o-acetylcholine PCho and CTP are condensed to CDP-Cho by PCYT1 dimer CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane PA is dephosphorylated to DAG by LPIN Synthesis of PC <i>De novo</i> (Kennedy pathway) synthesis of phosphatidylcholine (PC) involves phosphorylation of choline (Cho) to phosphocholine (PCho) followed by condensing with cytidine triphosphate (CTP) to form CDP-choline (CDP-Cho). Diacylglycerol (DAG) and CDP-ETA together then form PC. Alternatively, PC is formed when phosphatidylethanolamine (PE) is methylated by phosphatidylethanolamine N-methyltransferase (PEMT) (Henneberry et al. 2002; Wright & McMaster 2002). Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006656 Pubmed12216837 Pubmed12221122 Reactome Database ID Release 431483191 Reactome, http://www.reactome.org ReactomeREACT_121238 Reviewed: Wakelam, Michael, 2012-05-14