PathwayStep1713 PathwayStep1715 PathwayStep1714 PathwayStep1716 PC:PITPNB is transported from the Golgi membrane to the ER membrane PC is exchanged with PI by PITPNB PI is exchanged with PC by PITPNB PI:PITPNB is transported from the ER membrane to the Golgi membrane PI and PC transport between ER and Golgi membranes Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0015914 Pubmed16854452 Pubmed18636990 Pubmed20332109 Pubmed21915936 Reactome Database ID Release 431483196 Reactome, http://www.reactome.org ReactomeREACT_121079 Reviewed: Wakelam, Michael, 2012-05-14 The phosphatidylinositol transfer protein beta isoform (PITPNB) bound to phosphatidylinositol (PI) complex transports from the endoplasmic reticulum (ER) membrane to the Golgi membrane, where phosphatidylcholine (PC) is exchanged for PI. PITPNB now in complex with PC transports back to the ER membrane where PI is now exchanged for PC, and the cycle repeats. This process has been characterized in detail in bovine and rodent model systems (e.g., Wirtz et al. 2006; Ghosh and Bankaitis 2011), which provide a framework for organizing the more limited data available for the very well conserved human proteins and processes( Carvou et al. 2010, Shadan et al. 2008).