PathwayStep1720 PathwayStep1724 PathwayStep1723 PathwayStep1722 PathwayStep1721 PathwayStep1725 PathwayStep1719 PathwayStep1718 PC is hydrolyzed to 1-acyl LPC by PLA2[5] PC is hydrolyzed to 1-acyl LPC by PLA2[6] PC is hydrolyzed to 2-acyl LPC by PLA2G4C 1-acyl LPC is acylated to PC by LPCAT PC is hydrolysed to 2-acyl LPC by PLA2[7] PC is hydrolyzed to 1-acyl LPC by PLA2[16] 2-acyl LPC is acylated to PC by LPCAT PC is hydrolyzed to 1-acyl LPC by PLB1 Acyl chain remodelling of PC Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0036151 In the acyl chain remodelling pathway (Lands cycle), phosphatidylcholine (PC) is hydrolysed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Zhao et al. 2008). Pubmed12359733 Pubmed18195019 Pubmed18458083 Pubmed20705608 Reactome Database ID Release 431482788 Reactome, http://www.reactome.org ReactomeREACT_120829 Reviewed: Wakelam, Michael, 2012-05-14