thrombin:cleaved antithrombin III thrombin:cleaved antithrombin III:heparin Heparin thrombin:cleaved antithrombin III:heparin -> thrombin:cleaved antithrombin III + heparin Authored: D'Eustachio, P, 2004-08-24 14:00:00 Pubmed12907439 Reactome Database ID Release 43140872 Reactome, http://www.reactome.org ReactomeREACT_1283 The same conformational change that traps thrombin in its complex with cleaved antithrombin III also decreases the affinity of the latter for heparin, and the complex of cleaved antithrombin III and thrombin dissociates from the cell-bound heparin molecule.