activated protein C protein C protein C -> activated protein C + protein C heavy chain activation peptide Authored: Ouwehand, W.H., 2007-11-12 16:45:54 EC Number: 3.4.21 Pubmed2538457 Pubmed468991 Reactome Database ID Release 43141040 Reactome, http://www.reactome.org ReactomeREACT_374 Reviewed: Zwaginga, JJ, 2007-11-12 16:47:00 Thrombin complexed with thrombomodulin at the endothelial cell surface cleaves the heavy chain of protein C, generating activated protein C and an activation peptide. The activation peptide has no known function.