PathwayStep1680 PathwayStep1676 PathwayStep1675 PathwayStep1678 PathwayStep1677 PathwayStep1679 DAG is acylated to TAG by DGAT1/2 TAG is hydrolyzed to DAG by PNPLA2/3 2-MAG is hydrolyzed to fatty acid and glycerol by MGLL 2-MAG and DAG are transacylated to TAG by PNPLA2/3 2-MAG is transacylated to DAG by PNPLA2/3 DAG is hydrolyzed to 2-MAG by PNPLA2/3 Acyl chain remodeling of DAG and TAG Acyl chain remodeling of triacylglycerol (TAG) and diacylglycerol (DAG) progresses through their hydrolysis by patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3). DAG is reacylated back to TAG by acylglycerol O-acyltransferase 1/2 (DGAT1/2), while DAG and its hydrolysis product 2-monoacylglycerol (2-MAG) are transacylated back to TAG by PNPLA2/3. In addition, the DAG hydrolysis product 2-MAG is subsequently hydrolyzed to fatty acid and glycerol by monoglyceride lipase (MGLL) (Jenkins et al. 2004). Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0036155 Pubmed15364929 Reactome Database ID Release 431482883 Reactome, http://www.reactome.org ReactomeREACT_121122 Reviewed: Wakelam, Michael, 2012-05-14