PathwayStep1673 PathwayStep1666 PathwayStep1667 PathwayStep1668 PathwayStep1669 PathwayStep1670 PathwayStep1672 PathwayStep1671 PathwayStep1286 PathwayStep1290 PathwayStep1288 PA is hydrolyzed to 1-acyl LPA by PLA2[15] PC is hydrolyzed to PA and choline by PLD1/2 G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM) PA is hydrolysed to 1-acyl LPA by PLA2G2A PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM) 1-acyl LPA is acylated to PA by AGPAT5 (OM) PA is hydrolysed to 1-acyl LPA by PLA2[1] DHAP is converted to 1-acyl GO3P by GNPAT DHAP is converted to G3P by GPD1/GPD1L G3P is acylated to 1-acyl LPA by AGPAT6 1-acyl LPA is acylated to PA by AGPAT (LPAAT) Synthesis of PA Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006654 In the <i>de novo</i> synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of <i>sn-1</i> by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosphate (G3P). Next, LPA is converted to PA by a LPA acyltransferase (AGPAT, also known as LPAAT). In addition to this, PA is also formed when phosphatidylcholine (PC) is hydrolyzed by phospholipase D1/2 (PLD1/2). PA is involved in acyl chain remodeling via cleavage by phospholipases followed by reacylation by acyltransferases (Ghomashchi et al. 2010, Singer et al. 2002, Prasad et al. 2011, Shindou & Shimizu 2009, Cao et al. 2006). Pubmed12359733 Pubmed17170135 Pubmed18718904 Pubmed20705608 Pubmed21173190 Reactome Database ID Release 431483166 Reactome, http://www.reactome.org ReactomeREACT_120906 Reviewed: Wakelam, Michael, 2012-05-14