PathwayStep1627 PathwayStep1629 PathwayStep1628 PathwayStep1631 PathwayStep1632 PathwayStep1630 PathwayStep1633 Conversion of 18-hydroxycorticosterone to aldosterone 11-deoxycorticosterone translocates from the cytosol to the mitochondrial matrix Hydroxylation of corticosterone to form 18-hydroxycorticosterone Hydroxylation of 11-deoxycorticosterone to form corticosterone Pregn-5-ene-3,20-dione isomerizes to progesterone 21-hydroxylation of progesterone to form 11-deoxycorticosterone Pregnenolone + NAD+ => pregn-5-ene-3,20-dione + NADH + H+ Mineralocorticoid biosynthesis Aldosterone, the major human mineralocorticoid, is synthesized in the zona glomerulosa of the adrenal cortex from pregnenolone. Pregnenolone is converted to progesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. Progesterone is hydroxylated by CYP21A2 to form deoxycorticosterone, which in turn is converted to aldosterone in a three-reaction sequence catalyzed by CYP11B2 (Payne and Hales 2004). Authored: Jassal, B, 2008-10-01 13:18:42 Edited: Jassal, B, 2007-04-20 21:09:56 GENE ONTOLOGYGO:0006705 Pubmed15583024 Reactome Database ID Release 43193993 Reactome, http://www.reactome.org ReactomeREACT_11047 Reviewed: D'Eustachio, P, 2007-04-20 21:11:21