PathwayStep1662 PathwayStep1663 PathwayStep1659 PathwayStep1661 PathwayStep1660 PathwayStep1198 RDH11 reduces RBP2:atRAL to RBP2:atROL BCMO1:Fe2+ oxidises betaC to atRAL atROL binds to RBP2 to form RBP2:atROL PLB1 hydrolyses RPALM to atROL LRAT esterifies RBP2:atROL to atREs PNLIP:CLPS hydrolyses RPALM to atROL and PALM Retinoid metabolism and transport Authored: Jassal, B, 2010-10-01 Authored: Stephan, R, 2010-09-19 Edited: Jassal, B, 2010-10-01 GENE ONTOLOGYGO:0001523 Pubmed11340090 Pubmed16011460 Reactome Database ID Release 43975634 Reactome, http://www.reactome.org ReactomeREACT_24968 Reviewed: D'Eustachio, P, 2010-11-09 Vitamin A (all-trans-retinol) must be taken up, either as carotenes from plants, or as retinyl esters from animal food. The most prominent carotenes are alpha-carotene, lycopene, lutein, beta-cryptoxanthine, and especially beta-carotene. After uptake they are mostly broken down to retinal. Retinyl esters are hydrolysed like other fats. In enterocytes, retinoids bind to retinol-binding protein (RBP). Transport from enterocytes to the liver happens via chylomicrons (Harrison & Hussain 2001, Harrison 2005).